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Amide compounds, methods for preparation, and use thereof as agents for the treatment and prevention of diseases caused by RNA- and/or DNA-containing viruses, and concomitant diseases

机译:酰胺化合物,其制备方法及其用作治疗和预防由含RNA和/或DNA的病毒引起的疾病以及伴随疾病的试剂

摘要

This invention relates to the field of medicine and concerns a method for the prophylaxis or treatment of diseases caused by RNA- and DNA-containing viruses, and concomitant diseases, which envisages the use of an effective amount of a compound of general formula I or a pharmaceutically acceptable salt thereof. The invention also relates to methods for producing the aforesaid compounds, and to pharmaceutical compositions for the prophylaxis or treatment of diseases caused by RNA- and DNA-containing viruses, which contain an effective amount of a compound of general formula I or a pharmaceutically acceptable salt thereof. The invention solves the problem of providing a novel agent effective in the treatment of diseases caused by RNA-containing viruses belonging to the enterovirus genus, the metapneumovirus genus, the pneumovirus genus, the respirovirus genus or the alphacoronavirus genus, and DNA-containing viruses belonging to the adenovirus family and the herpesvirus family, and also effective in the prophylaxis and treatment of asthma exacerbations, chronic obstructive pulmonary disease, cystic fibrosis, conjunctivitis, gastroenteritis, hepatitis and myocarditis, and in the prophylaxis and treatment of rhinorrhea, acute and infectious rhinitis, pharyngitis, nasopharyngitis, tonsillitis, laryngitis, laryngotracheitis, laryngotracheobronchitis, bronchitis, bronchiolitis, pneumonia or obstructive airways syndrome.
机译:本发明涉及医学领域,涉及一种预防或治疗由含RNA和DNA的病毒引起的疾病以及伴随疾病的方法,其设想使用有效量的通式I的化合物或药物。其药学上可接受的盐。本发明还涉及产生上述化合物的方法,以及用于预防或治疗由含RNA和DNA的病毒引起的疾病的药物组合物,其包含有效量的通式I化合物或药学上可接受的盐。其。本发明解决了提供有效治疗由肠道病毒属,间质肺病毒属,肺炎病毒属,呼吸道病毒属或α冠状病毒属的含RNA病毒引起的疾病的问题,以及提供一种新的药剂的问题。腺病毒家族和疱疹病毒家族,并且在预防和治疗哮喘急性发作,慢性阻塞性肺疾病,囊性纤维化,结膜炎,胃肠炎,肝炎和心肌炎以及预防和治疗鼻漏,急性和感染性鼻炎方面也有效,咽炎,鼻咽炎,扁桃体炎,喉炎,喉气管炎,喉气管支气管炎,支气管炎,细支气管炎,肺炎或阻塞性气道综合征。

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