VECTOR LIBRARY FOR YEAST TWO HYBRID SCREENING AND METHOD FOR IDENTIFYING DEUBIQUITINATING ENZYME BINDING TO TARGET PROTEIN USING SAME

摘要

The present invention provides a vector library for yeast two hybrid screening of a deubiquitinating enzyme binding to a target protein and a method for identifying a deubiquitinating enzyme binding to a target protein using the same. In addition, provided, in the present invention, is a screening method of a substance having anticancer activity targeting deubiquitinating enzymes USP1, USP7, USP12, or USP49 identified by the identification method.