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CARDIAC REPAIR BY REPROGRAMMING OF ADULT CARDIAC FIBROBLASTS INTO CARDIOMYOCYTES

机译：通过将成人心脏成纤维细胞重编程为心肌细胞来进行心脏修复

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摘要

The present disclosure involves the use of reprogramming factors including AKT1, GATA4, TBX5, MEF2C, HAND2 and either ZNF281 or ASCLl to reprogram adult non- cardiomyocytes, such as cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo. Such methods find particular use in the treatment of patients post-myocardial infarction to prevent or limit scarring and to promote myocardial repair.

机译：本公开涉及使用重编程因子（包括AKT1，GATA4，TBX5，MEF2C，HAND2和ZNF281或ASCL1）将成年非心肌细胞（例如心脏成纤维细胞）重编程为体外和<在体内。这类方法在治疗心肌梗塞后的患者中特别有用，可预防或限制瘢痕形成并促进心肌修复。 展开▼

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公开/公告号WO2019036086A1

专利类型

公开/公告日2019-02-21

原文格式PDF

申请/专利权人 THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM;
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申请/专利号WO2018US35830

发明设计人 OLSON ERIC N.;ZHOU HUANYU;BASSEL-DUBY RHONDA;
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申请日2018-06-04

分类号C12N5/07;C12N5/074;C07K14/47;A61K38/18;

国家 WO

入库时间 2022-08-21 11:56:29

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1. 将成纤维细胞直接重编程为成骨细胞的基质材料及制备方法和重编程方法 [P] . 中国专利： CN113846054A . 2021-12-28

2. 由成纤维细胞直接制造心脏祖细胞和心肌细胞的方法 [P] . 中国专利： CN109072220A . 2018-12-21

3. CARDIAC REPAIR BY REPROGRAMMING OF ADULT CARDIAC FIBROBLASTS INTO CARDIOMYOCYTES [P] . US2021180023A1 . 2021-06-17

机译：通过将成人心脏成纤维细胞重新编程成心肌细胞的心脏修复

4. Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes [P] . 美国专利： US9523079B2 . 2016-12-20

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5. Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes [P] . AU2012220702B2 . 2016-12-15

机译：通过将心脏成纤维细胞重编程为心肌细胞来进行心脏修复

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