USE OF BUTYRIC ACID COMPOUND IN PREPARATION OF DRUG FOR PREVENTING AND TREATING NEC OR NUTRITION PREPARATION

摘要

Provided in the present invention is the use of a butyric acid compound in the preparation of a drug for preventing and treating necrotizing enterocolitis or a nutrition preparation, also provided is a nutrition preparation containing butyric acid which comprises a nutritional composition and a butyric acid compound, wherein the concentration of the butyric acid compound in the nutrition preparation is 0.5 to 200 mM (mmol/L). The butyric acid compound is selected from at least one of butyric acid, butyrate salts, and butyric acid derivatives. The present invention first finds that the butyric acid compound is very effective in preventing and treating necrotizing enterocolitis by adding it to a pharmaceutical or nutritional composition, including significantly reducing the incidence and mortality of necrotizing enterocolitis, shortening the duration of necrotizing enterocolitis, reducing its complications and/or reducing its severity. At the same time it also has the effects of promoting growth, immune system development and intestinal maturation.