Modeling miRNA induced silencing in breast cancer with paradigm

摘要

A probabilistic graphical pathway model is modified to include miRNA regulation by adding RISC as a regulatory factor. Most preferably, the pathway model is built using factor graphs, and the RISC includes DICER, TARBP2, and AGO2 or AGO1/3/4. So constructed pathway models can be used to infer RISC activity, which can be associated with various clinically relevant parameters to build various predictors or diagnostic tests.