Perm selective membrane for treating vascular calcification in chronic hemodialysis patients

摘要

Abstract The present disclosure relates to a hemodialysis membrane for the treatment of vascular calcification in hemodialysis patients, especially in chronic hemodialysis patients. The 5 present disclosure further relates to methods of treating vascular calcification in hemodialysis patients, wherein the hemodialysis membrane is characterized in that it comprises at least one hydrophobic polymer and at least one hydrophilic polymer and in that it has a MWRO of between 15 and 20 kD and a 0 MWCO of between 170-320 kD or that the hemodialysis membrane comprises at least one hydrophobic polymer and at least one hydrophilic polymer and has a MWRO of between 8.5 kD and 14.0 kD and a MWCO of between 55 kD and 130 kD. (Fig. 4) 5863330_2 (GHMatters) P98259.AU.1 A ALP activity C Calcium deposition 150- 200 100- -. E 100-- * -50- "''''.... _ __ =L 0 0 Conventional HCO Conventional HCO 1.0- 1.0 0.8- 0.8 00.6- 0.6 0.4- 0.4 0.2- 0.2 0.0o 0.0 Conventional HCO Conventional HCO Figure 4