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SERIES OF DIMERIC INDOLE ALKALOID COMPOUNDS, PREPARATION METHOD THEREFOR AND USE OF SAME IN PREPARATION OF ANTIBACTERIAL DRUGS

机译：系列二吲哚类生物碱化合物，其制备方法及其在制备抗菌药物中的用途

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摘要

The present invention falls within in the fields of organic synthesis and pharmaceutical chemistry. In particular, the present invention relates to a series of dimeric indole alkaloid compounds as shown in structural general formula I, preparation methods therefor and the use of same in the preparation of antibacterial drugs. After same undergo in vitro activity screening, the results show that such compounds have strong antibacterial activity, in particular have specific inhibitory effects on gram-positive bacteria, such as strains of staphylococcus, bacillus and enterococcus, and related drug-resistant strains thereof, and can be used as the lead compounds for developing new antibacterial drugs.

机译：本发明属于有机合成和药物化学领域。特别地，本发明涉及一系列如结构通式I所示的二聚吲哚生物碱化合物，其制备方法及其在制备抗菌药物中的用途。对它们进行体外活性筛选后，结果表明此类化合物具有较强的抗菌活性，特别是对革兰氏阳性细菌（如葡萄球菌，芽孢杆菌和肠球菌菌株及相关菌株）具有特异性抑制作用。其抗药性菌株，可用作开发新型抗菌药物的先导化合物。 展开▼

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公开/公告号WO2019072112A1

专利类型

公开/公告日2019-04-18

原文格式PDF

申请/专利权人 SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES;
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申请/专利号WO2018CN108524

发明设计人 GUO YUEWEI;LAN LEFU;LI XUWEN;CHEN FEIFEI;LIU JIN;
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申请日2018-09-29

分类号C07D413/14;A61P31/04;

国家 WO

入库时间 2022-08-21 11:55:12

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2. 一类二聚吲哚生物碱类化合物、其制备方法及其在制备抗菌药物中的应用 [P] . 中国专利： CN109651352A . 2019-04-19

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