DEVICES FOR APPLYING FORCES TO FERROMAGNETIC PROBES AT BOTH CELLULAR AND TISSUE LEVELS

摘要

An electromagnetic device comprises an elongated magnetic core member, a solenoid member and core cooling means for cooling the core member and solenoid cooling means for cooling the solenoid member. The core member comprises a cylindrical main region and a tapered end region with an asymmetrically tapered shape having a tip region. The core cooling means comprise a water-coolable cooling block and the solenoid cooling means comprise a plurality of cooling fins configured for air cooling by means of an external airstream. A magnetic tweezer device comprises at least one electromagnetic device and further comprises power supply means for driving an electrical current through the solenoid member, a holder system comprising a sample support and means for adjustably holding each electromagnetic device in a predetermined position and orientation with respect to the sample support, and means for observing a sample arranged on the sample support.