HEPATIC INFLAMMATION ANALYSIS WITH DYNAMIC PET

摘要

A system and method for determining kinetic parameters associated with a kinetic model of an imaging agent in a liver is provided. An image reconstruction device can receive radiotracer activities corresponding to a predetermined time period. For example, these radiotracer activities can include PET scan data corresponding to a number of time frames. The radiotracer activities can be used to determine a liver time activity curve and a circulatory input function. The liver time activity curve and circulatory input function can be used along with a kinetic model of the liver to produce kinetic parameters. These kinetic parameters can be used to determine hepatic scores, such as a hepatic steatosis score, a hepatic inflammation score, and a cirrhosis score. These scores are indicative of diseases of the liver, including nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and hepatic fibrosis.