CANCER THERAPEUTIC TARGETING USING MUTANT P53-SPECIFIC SIRNAS

摘要

Disclosed herein are nucleic acid sequences for targeting one or more point mutations within p53 gene. In particular, the site of point mutation in p53 is selected from the group consisting of R249, R248, R273 & R175. Also disclosed herein are methods for treating cancer in a subject, the method comprising administering to the subject one or more nucleic acid sequences disclosed herein.