首页> 外国专利> INHIBITOR OF EXPRESSION OF BONE FORMATION-RELATED FACTOR OR CALCIFICATION-RELATED FACTOR IN EXTRASKELETAL TISSUE

INHIBITOR OF EXPRESSION OF BONE FORMATION-RELATED FACTOR OR CALCIFICATION-RELATED FACTOR IN EXTRASKELETAL TISSUE

机译:抑制骨骼外组织中骨形成相关因子或钙化相关因子的表达

摘要

Provided is an inhibitor of the expression of a bone formation-related factor or a calcification-related factor in an extraskeletal tissue. An inhibitor of the expression of a bone formation-related factor in an extraskeletal tissue, the inhibitor being characterized by comprising phytic acid. The bone formation-related factor is any one of ALPL, RUNX2, BGLAP and the like. An inhibitor of the expression of a calcification-related factor in an extraskeletal tissue, the inhibitor being characterized by comprising phytic acid. The calcification-related factor is any one of SLC20A1, SLC20A2, ENPP1, ALPL, SPP1 and the like. These inhibitors can prevent heterotopic ossification and ectopic calcification, respectively, when administered intravenously.
机译:提供了在骨骼外组织中骨形成相关因子或钙化相关因子表达的抑制剂。骨骼外组织中骨形成相关因子表达的抑制剂,其特征在于包含植酸。骨形成相关因子是ALPL,RUNX2,BGLAP等中的任何一种。在骨骼外组织中钙化相关因子表达的抑制剂,其特征在于包含植酸。钙化相关因子是SLC20A1,SLC20A2,ENPP1,ALPL,SPP1等中的任何一种。当静脉内给药时,这些抑制剂可以分别防止异位骨化和异位钙化。

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