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PLATFORM FOR ASSESSMENT OF THE TRANSCYTOSIS OF EXTRACELLULAR VESICLES ACROSS ENDOTHELIAL BARRIERS AND USES THEREOF
PLATFORM FOR ASSESSMENT OF THE TRANSCYTOSIS OF EXTRACELLULAR VESICLES ACROSS ENDOTHELIAL BARRIERS AND USES THEREOF
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机译:跨内皮障碍物评估胞外血管转运的平台及其用途
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摘要
Provided herein are methods of determining whether an extracellular vesicle (EV) can cross an endothelial barrier (e.g., the blood brain barrier). In some embodiments, the EV originates from a cancer cell. In some embodiments, the cancer has a higher likelihood of metastasizing (to the brain) if the EV originating from a cancer cell is determined to be able to cross an endothelial barrier (e.g., the blood brain barrier). Thus, further provided herein are methods of determining whether a subject who has cancer is likely to develop metastatic cancer. In some embodiments, the subject is treated for the metastatic cancer accordingly.
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