ANTI-LEPTIN AFFINITY REAGENTS FOR USE IN THE TREATMENT OF OBESITY AND OTHER LEPTIN-RESISTANCE ASSOCIATED DISEASES

摘要

The present invention relates to anti-leptin affinity ligands (e.g. anti-leptin antibodies) that specifically bind leptin and reduce its serum levels for use in a method of treating a leptin- resistance associated disease, such as obesity and/or overweight, in a subject in need thereof. It further relates to compositions comprising the same, as well as methods of treatment comprising administration of a therapeutically effective dosage thereof.