首页> 外国专利> 4—(1H— IMIDAZOL— 5— YL) -1H-PYRROLO 2, 3-B PYRIDINES FOR USE IN THE TREATMENT OF LEUKAEMIAS, LYMPHOMAS AND SOLID TUMORS

4—(1H— IMIDAZOL— 5— YL) -1H-PYRROLO 2, 3-B PYRIDINES FOR USE IN THE TREATMENT OF LEUKAEMIAS, LYMPHOMAS AND SOLID TUMORS

机译：4-（1H-咪唑-5-YL）-1H-吡咯[2，3-B]吡啶类化合物用于白血病，淋巴瘤和固体肿瘤的治疗

页面导航

摘要
著录项
相似文献

摘要

The present invention relates to novel 4-(1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine compounds which are useful in the treatment of lymphomas, leukaemias, and solid tumors.

机译：本发明涉及新颖的4-（1IH -咪唑-5-基）-1 H -吡咯并[2,3- b ]吡啶化合物，可用于治疗淋巴瘤，白血病和实体瘤。 展开▼

著录项

公开/公告号WO2019185631A1

专利类型

公开/公告日2019-10-03

原文格式PDF

申请/专利权人 MASARYKOVA UNIVERZITA;
展开▼

申请/专利号WO2019EP57595

发明设计人 BRYJA VITEZSLAV;JANOVSKA PAVLINA;GREGOROVA MICHAELA;NEMEC VACLAV;KHIRSARIYA PRASHANT;PARUCH KAMIL;
展开▼

申请日2019-03-26

分类号C07D471/04;A61K31/4745;A61P35;

国家 WO

入库时间 2022-08-21 11:53:02

相似文献

专利

外文文献

中文文献

1. 4-(1H-咪唑-5-基)-1H-吡咯并2,3-B吡啶在治疗白血病、淋巴瘤和实体瘤中的用途 [P] . 中国专利： CN111936496A . 2020-11-13

2. 用于治疗病毒疾病的(S)-1-((S)-2-{5-4-(4-{2-(S)-1-((S)-2-甲氧羰基氨基-3-甲基-丁酰基)-吡咯烷-2-基-3H-咪唑-4-基}-丁-1,3-二炔基)-苯基-1H-咪唑-2-基}-吡咯烷-1-羰基)-2-甲基-丙基-氨基甲酸烷基酯萘-1,5-二磺酸盐 [P] . 中国专利： CN105073734A . 2015-11-18

3. 4—(1h— imidazol— 5— yl) -1h-pyrrolo (2, 3-b) pyridines for use in the treatment of leukaemias, lymphomas and solid tumors [P] . AU2019246220A1 . 2020-07-09

机译：用于治疗白血病，淋巴瘤和实体瘤的4-（1h-咪唑-5-基）-1h-吡咯并（2，3-b）吡啶

4. 4—(1h— imidazol— 5— yl) -1h-pyrrolo (2, 3-b) pyridines for use in the treatment of leukaemias, lymphomas and solid tumors [P] . AU2019246220B2 . 2020-10-08

机译：用于治疗白血病，淋巴瘤和实体瘤的4-（1h-咪唑-5-基）-1h-吡咯并（2，3-b）吡啶

5. 4 - (1h-imidazol-5-yl) - 1H-pyrrolo 2,3-b pyridine for use in the treatment of leukemia, lymphoma and solid tumors [P] . JP2021517157A . 2021-07-15

机译： 4 - （1H-咪唑-5-基） - 1H-Pyrrolo [2,3-B]吡啶用于治疗白血病，淋巴瘤和实体瘤

1. Vorolanib, an oral VEGFR/PDGFR dual tyrosine kinase inhibitor for treatment of patients with advanced solid tumors: An open-label,phase Ⅰ dose escalation and dose expansion trial [J] . Yan Song, Jinwan Wang, Xiubao Ren, 中国癌症研究（英文版） . 2021,第001期

2. Fusion genes in solid tumors:an emerging target for cancer diagnosis and treatment [J] . Brittany C. Parker, Wei Zhang 癌症（英文版） . 2013,第011期

3. Palliative Local Radiotherapy in the Treatment of Tumor-stage Cutaneous T-cell Lymphoma/Mycosis Fungoides [J] . Chen-chen Xu, Tao Zhang, Tao Wang, 中国医学科学杂志（英文版） . 2014,第001期

4. Synthesis and antidiabetic activity of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo(2,3-b)pyridines and thieno(2,3-b)pyridines. [J] . Bahekar RH, Jain MR, Jadav PA, Bioorganic and medicinal chemistry . 2007,第21期

5. Synthesis and antidiabetic activity of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines and thieno[2,3-b]pyridines [J] . Rajesh H. Bahekar, Mukul R. Jain, Pradip A. Jadav, Bioorganic and Medicinal Chemistry . 2007,第21期

6. 3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, Nortopsentin Analogues with Antiproliferative Activity [J] . Alessandra Montalbano, Alessandro Attanzio, Anake Kijjoa, Marine Drugs . 2015,第4期

7. Synthesis and Photophysical Properties of a Copper(I) Complex Emitting Material Containing 5-(9H-fluoren-2-yl)-2-(1H-imidazol-2-yl)Pyridine Ligand [C] . Chaoyang Chai, Qingzhi Su, Feng Zhao International Conference on Energy and Environmental Protection . 2018

8. Chromosomal aberrations in the tumor and peripheral blood and changes in aberrations during treatment of canine lymphoma. [D] . Devitt, Jennifer J. 2008

9. 2-(3,4,5-Trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine [O] . Roland Selig, Dieter Schollmeyer, Wolfgang Albrecht, 2016

10. 3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, Nortopsentin Analogues with Antiproliferative Activity [O] . Barbara Parrino, Anna Carbone, Gloria Di Vita, 2015

1. Synthesis, Structure, and Luminescent and Dielectric Properties of Two Novel 1D Chains Based on a T-Shaped Tripodal Ligand 4-(4,5-Dicarboxy-1H-imidazol-2-yl)pyridine Loxide [J] . CHEN Li-Zhuang ,JI Qin ,DAN Yuan-Yuan . 结构化学 . 2016,第011期

2. Diagnosis and treatment of solidpseudopapillary tumors of the pancreas [J] . Xi Chen Guang-Wen Zhou Hui-Jiang Zhou Cheng-Hong Peng and Hong-Wei Li Department of Surgery Shanghai Institute of Digestive Surgery Ruijin Hospital Shanghai Second Medical University Shanghai 200025 China . 国际肝胆胰疾病杂志：英文版 . 2005,第3期

3. 4-(3-吡啶基)-1H-咪唑-1-丁胺的合成研究进展 [C] . 范新苑 ,孙立权 ,刘聪 . 第六届全国试剂与应用技术交流会 . 2012

4. 1-(4-溴苯基)-2-(2-甲基-4-硝基-1H-咪唑-1-基)乙酮肟衍生物的合成及其生物活性研究 [A] . 郭凤娇 . 2015