A MICROFLUIDIC DEVICE FOR PATTERNING CELLULAR MATERIAL IN A 3D EXTRACELLULAR ENVIRONMENT

摘要

The present disclosure relates to a method for arranging cellular material in a bioink, gel or hydrogel material used in3D-bioprinting. The method comprises bioprinting or dispensing at least one layer of bioink/gel/hydrogel, dispensing or patterning cellular material in the form of single cells, spheroids or cell suspension on or in the bioink/gel/hydrogel layer using a microfluidic device, and repeating previous steps in order to create a 3D tissue model with multiple cell layers.The present disclosure also relates to corresponding microfluidic devices, computer programs and 3D bioprinters.