METHOD FOR PREPARING ESTERS OF N-ACYLATED AMINO ACIDS WITH ACID-LABILE KETONE PROTECTIVE GROUP FUNCTIONS

摘要

The present invention relates to a new method for the esterification of N-acylated amino acids containing an acid-labile ketone protective group under alkaline conditions without the use of a polar aprotic solvent, by esterifying the N-acylated amino acid prepared in situ with an acid-labile ketone protective group using an alkyl halide or a mono- or dialkyl ester of sulphuric acid.