GENOTYPING ASSAYS TO IDENTIFY MUTATIONS IN XAF1

摘要

Methods and compositions are provided for monitoring, treating, and identifying subjects at risk of developing a cell-proliferative disorder. Mutations in XAF1 have been identified that can result in reduced XAF1 activity and a higher risk of developing cancer. Thus, by detecting mutations in an XAF1 polynucleotide that reduce XAF1 activity, subjects at risk of developing a cell-proliferative disorder can be identified so that risk-adaptive therapy can be implemented or surveillance of the subject increased in order to reduce symptoms of the disorder. Further provided are compositions and kits for the detection of mutations in a XAF1 polynucleotide.