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COMPOSITIONS AND METHODS FOR TREATING GLIOBLASTOMA BY MODULATING A MGMT ENHANCER
COMPOSITIONS AND METHODS FOR TREATING GLIOBLASTOMA BY MODULATING A MGMT ENHANCER
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机译:通过调节MGMT增强剂治疗胶质母细胞瘤的组合物和方法
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摘要
The present invention provides, inter alia, methods for treating or ameliorating the effects of a cancer in a subject, e.g., glioblastoma (GBM) in a subject that is resistant to temozolomide (TMZ), methods for delaying the emergence of TMZ resistance and/or increasing the TMZ sensitivity in a subject, and methods for reducing tumor aggressiveness in a subject. Also provided are pharmaceutical compositions and kits to implement such methods.
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