HIGH AFFINITY MONOCLONAL ANTIBODIES (MABS) AGAINST CELL SURFACE EXPRESSED HUMAN CARBONIC ANHYDRASE IX (HCA-IX), AND USES THEREOF

摘要

The present invention provides a set of Carbonic Anhydrase-IX monoclonal antibodies (CA-IX mAbs) that bind with high affinity to cell-surface expressed hCA-IX and has enzyme inhibiting characteristics. These mAbs have the potential to become the next biologics for the treatment of renal and possibly other types of cancer.