ALKYNYL-CONTAINING RUTHENIUM COMPLEX, AND SYNTHESIS METHOD THEREFOR AND USE THEREOF

摘要

Provided is an alkynyl-containing ruthenium complex, and also involved are a method for synthesizing the alkynyl-containing ruthenium complex and the use thereof. The alkynyl-containing ruthenium complex is a new type of ruthenium complex, and an alkynyl is introduced into the DPPZ-type ruthenium complex by means of the Sonogashira coupling reaction. The introduced alkynyl is favorable for promoting the transmembrane absorption of drug molecules, improves the probability of drugs entering cells, and can also enhance the pharmaceutical efficacy and lower the toxicity and side effects of the drugs. The alkynyl-containing ruthenium complex provided in the invention has a significant anti-tumor activity, in particular an anti-breast cancer activity, and at the same time, provides a new idea for the design of future anti-tumor drug molecules. The alkynyl-containing ruthenium complex provided in the invention can also be used as a fluorescent probe. In a word, the alkynyl-containing ruthenium complex has broad prospects for use in the field of medicinal chemistry.