DRUG FOR USE IN COMBINATION, AND USE THEREOF FOR PREPARING DRUGS FOR TREATMENT OF HIGH-GRADE BRAIN TUMORS IN RESPONSE TO INEFFECTIVE STANDARD TREATMENT FOR POSTOPERATIVE RECURRENCE

摘要

A drug for use in combination for treating high-grade brain tumors in response to ineffective standard treatment for postoperative recurrence. The drug for use in combination comprises chlorogenic acid and temozolomide of the same or different unit preparations for simultaneous or separate administration, and a pharmaceutically acceptable carrier. Provided are a pharmaceutical composition comprising chlorogenic acid and temozolomide, a method for preparing the same, and a use of the drug for use in combination and the pharmaceutical composition for preparing a drug for treatment of high-grade brain tumors for which standard treatment for postoperative recurrence is ineffective.