Herbal medicine poisoned Zika virus vaccine

摘要

The present invention relates to a vaccine composition comprising an attenuated zicavirus and a vaccine, an attenuated chimeric zucavirus and a vaccine, and a vaccine against zicavirus and other flaviviruses. The chimeric chicca virus comprises a first nucleotide sequence encoding at least one structural protein from zikavirus (ZIKV), a second nucleotide sequence encoding at least one nonstructural protein from the first flavivirus, and a second nucleotide sequence encoding a second flavivirus The third nucleotide sequence of the 3 ''untranslated region from the nucleotide sequence of SEQ ID NO. The polynucleotide composition may comprise an attenuated ZIKV vaccine or an attenuated chimeric ZIKV vaccine (or a combination thereof) in combination with a first attenuated virus that is immunogenic against dengue serotype 1, a second attenuated virus against dengue serotype 2 Together with one or more of an immunogen-derived second attenuated virus, a third attenuated virus that is immunogenic against dengue serotype 3, and a fourth attenuated virus that is immunogenic against dengue serotype 4. The invention also relates to methods of inducing an immune response as well as preventing or treating ZIKV infection, and in particular embodiments, a method of preventing or treating ZIKV and other flaviviruses, e. G., Dengue virus .