A pharmaceutical composition for the prevention or treatment of dementia and improvement of cognitive function comprising extract of Salicornia europaea

摘要

The present invention relates to a pharmaceutical composition for preventing and treating dementia, or improving cognitive ability, comprising an Acanthoside B compound as an active ingredient. In the present invention, it was confirmed that a desalinated extract of Salicornia europaea and Acanthoside B, which is an acetylcholine esterase inhibitory active ingredient isolated from the extract, have excellent brain nerve cell protection activity through brain neuroinflammatory inhibition, and significantly enhanced memory and space recognition ability in a passive avoidance test and a Y-maze test of a scopolamine-induced memory degeneration animal model. According to the present invention, the Acanthoside B or the extract of Salicornia europaea can be applied to a pharmaceutical composition for preventing or treating dementia, a pharmaceutical composition for improving cognitive ability, or a health functional food or a feed for improving cognitive ability.