A manipulated parasite to deliver proteins to the central nervous system (CNS)

摘要

A nucleic acid construct, a toxoplasmic reticulum containing the same, a nucleic acid construct for treating a pathologic condition that is treatable by administration of a therapeutic polypeptide in the central nervous system of a subject, and further, to a tissue-of-interest of an individual such as the CNS , A pharmaceutical composition comprising the same, and a method using the same.