Glycoproteins with reduced acetylation rate of sialic acid residues

摘要

The present invention is a method or process for producing a glycoprotein having a modified activity that interacts with or acts as an agonist for the erythropoietin receptor (EpoR), wherein the method or process modifies the sugar Wherein at least one step is provided that results in a reduced acetylation rate of the sialic acid residue in the glycoprotein (Fig. 16).