Tumorigenic-specific enzyme sensitive-nanofiber coated gastrointestinal stent for eluting vorinostat

摘要

The present invention relates to a tumor-specific enzyme sensitive-nanofiber coated gastrointestinal stent for eluting vorinostat, and a method for producing the same. The method comprises the steps of: synthesizing a biodegradable polymer block copolymer by using specifically lysed glycine-phenylalanine-leucine-glycine (GFLG) peptide which is specifically degraded by cathepsin B; and dissolving the biodegradable polymer block copolymer and vorinostat in an organic solvent to form a spinning solution, and discharging the spinning solution to a stent body. Accordingly, vorinostat-contained nanofiber effective in inhibiting histone deacetylase is produced, and then applied to a biliary stent such that the biliary stent is highly usable as a medical device for treating biliary tract cancer occurring in the bile duct, one of the digestive organs in the human body. In addition, the biodegradable polymer can be covalently bonded to another polymer by means of peptide degraded by cathepsin B to produce a block copolymer, the block copolymer is used to produce vorinostat-contained nanofiber, and then the vorinostat-contained nanofiber is fixed to a biliary stent.