PHARMACEUTICAL COMPOSITION FOR TREATING INFLAMMATORY DISEASES CONTAINING ANTI-STAT3 BISPECIFIC ANTIBODY HAVING INTRACELLULAR PENETRATION ABILITY

摘要

The present invention relates to a pharmaceutical composition for treating inflammatory diseases containing an anti-STAT3 bispecific antibody having intracellular penetration ability as an active component. It is confirmed that a STAT3/DNA bispecific antibody according to the present invention comprises a DNA binding site, which allows penetration into cells and specifically binds to intranuclear DNA, so as to be capable of overcoming limitations of a conventional antibody drug, which only targets proteins existing outside cells, and binds specifically only to STAT3 in an active phosphorylated form to be capable of inhibiting the activity of a transcription factor thereof, thereby being able to be effectively used for the development of a therapeutic agent without side effects for inflammatory diseases including rheumatoid arthritis caused by the activation of STAT3.;COPYRIGHT KIPO 2019