Composition for inhibiting a growth of breast cancer stem cells comprising ciclesonide

摘要

The present invention relates to: a composition for suppressing cancer stem cell growth including ciclesonide or pharmaceutically acceptable salt thereof as an active ingredient; and a pharmaceutical composition and a food composition for inhibiting the metastasis of cancer or for treating or preventing cancer including the composition. The ciclesonide of the present invention inhibits the growth of breast cancer and lung cancer cells and the formation of breast cancer and lung cancer stem cells. The present invention is confirmed to: inhibit the expression of self-renewing genes such as Nanog, C-myc, Oct4, Sox2, Snail, and CD44 which are known to be characteristically expressed in breast cancer and lung cancer stem cells; inhibit the production of IL-6 and IL-8 which are known to be involved in the mammoth pair formation of breast cancer stem cells and the tumorous pair formation of lung cancer stem cells; and inhibit STAT3 signaling pathway. Accordingly, the compound inhibits the growth of cancer stem cells such as breast cancer and lung cancer, and the growth of the cancers and can be used for the treatment of cancers such as breast cancer and lung cancer.