Compression representation method and apparatus of bioinformatics data using multiple genome descriptors

摘要

A method and apparatus for compressing genomic sequence data generated by a genomic sequencing instrument. Sequence reads are coded by aligning them with respect to reference sequences that already exist or have been produced. The coding process consists of classifying reads into data classes and then coding each class in terms of a plurality of descriptor blocks. A particular source model and entropy coder is used for each data class and each associated descriptor block for which data is partitioned.