Extracellular Matrix (ECM) Hydrogels and Soluble Fractions thereof for Cancer Treatment

摘要

EXTRACELLULAR MATRIX (ECM) HYDROGEL AND SOLUBLE FRACTION THEREOF FOR THE TREATMENT OF CANCER Summary Methods for reducing tumor cell proliferation, increasing the death of tumor cells, and / or reducing the migration of tumor cells are disclosed. This method comprises contacting tumor cells with an effective amount of lysed extracellular matrix (ECM) hydrogel or a water soluble fraction thereof, thereby reducing tumor cell proliferation, increasing tumor cell death, and / or Reducing the migration of tumor cells. Also disclosed are methods for treating a subject with a tumor. The method includes administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a dissolved ECM soluble fraction and a pharmaceutically acceptable carrier, thereby treating the tumor in the subject. In particular non-limiting examples, the tumor is glioma and / or the ECM hydrogel is a bladder ECM hydrogel.