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D-methadone and its derivatives for use in the treatment of neurological disorders

机译:D-美沙酮及其衍生物,用于治疗神经系统疾病

摘要

The present invention relates to a method of treating or preventing cellular dysfunction and death caused by genetic, developmental, degenerative, toxic, traumatic, ischemic, infectious, neoplastic and inflammatory diseases and aging and their neurological symptoms and signs. The method, whether isolated from its enantiomers or neosynthesized, includes d-methedone, beta-d-methol, alpha-l-methol, beta-l-, including deuterated and tritium analogues. Metadol, alpha-d-methol, acetylmethol, d-alpha-acetylmethol, l-alpha-acetylmethol, beta-d-acetylmethol, beta-l-acetylmethol, d-alpha- Normethol, l-alpha normethol, noracetylmethol, dinonormethetadol, metadol, normetholdol, dinormethol, EDDP, EMDP, d-isomethedone, normethadone, N-methyl- Methadone, N-methyl-d-methedone, N-methyl-l-methadone, l-moramide, levopropoxyphene, these Administering a pharmaceutically acceptable salt or mixture.
机译:本发明涉及治疗或预防由遗传,发育,退化,毒性,外伤,局部缺血,感染,赘生性和炎性疾病和衰老及其神经系统症状和体征引起的细胞功能障碍和死亡的方法。该方法,无论是从其对映异构体中分离出来的还是新合成的,都包括d-甲基丁酮,β-d-甲醇,α-1-甲醇,β-1-,包括氘代和tri类似物。扑热息痛,α-d-羟甲基,乙酰基羟甲基,d-α-乙酰基羟甲基,l-α-乙酰基羟甲基,β-d-乙酰基羟甲基,β-1-乙酰基羟甲基,d-α-甲羟甲基,l-α-甲羟甲基,正乙酰基羟甲基,二nonormethetadol,metdol ,去甲甲酚,乙二甲酚,EDDP,EMDP,d-异美甲酮,去甲美沙酮,N-甲基-美沙酮,N-甲基-d-甲二酮,N-甲基-1-美沙酮,1-甲酰胺,左旋丙氧吩,这些药物上可接受的盐或混合物。

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