VLRB Fc Fusion protein comprising Fc domain from mouse antibody linked to hagfish VLRB protein with deleted hydrophobic tail domain and uses thereof

摘要

The present invention relates to a polynucleotide encoding an immunoglobulin Fc domain, which is sequentially connected to the 3'-end of a gene encoding a wild-type urea-derived variable lymphocyte receptor B (VLRB) protein from which a hydrophobic tail domain has been removed; Linker sequence; A recombinant expression vector comprising a polynucleotide encoding an immunoglobulin J chain, a host cell transformed with said recombinant expression vector, a horseshoe-derived VLRB protein from which said hydrophobic tail domain produced by said host cell has been removed; An immunoglobulin Fc domain; Linker; And an immunoglobulin J chain are sequentially connected to each other, and a fusion protein of the fusion protein is composed of a multimer or a tetrameric multimer.