Enhanced stimulation of stem cell regeneration by cellular interaction between mesenchymal stromal cells and endothelial cells

摘要

In the present invention, when vascular endothelial cells and mesenchymal stem cells are co-cultured, the neuronal activity of mesenchymal stem cells and the self-renewal ability of hematopoietic or neural stem cells are enhanced, and in particular, vascular endothelial cells (Cytokine, etc.), it was confirmed that the nicotine activity and the self regeneration ability of hematopoietic or neural stem cells can be easily controlled. Therefore, it is expected that the present invention not only improves the self-renewal ability of stem cells, but also can easily control the self-renewal ability of the stem cells as needed, thereby expanding the utility of mesenchymal stem cell-based cell therapy.