2D DNA Electrochemical Method for Detecting DNA using semiconductor 2-dimensional crystal

摘要

The present invention relates to a method for electrochemical detection of target DNA, which uses a semiconductor 2D crystal material to increase the detection speed, sensitivity, and selectivity more simply and efficiently. The method of the present invention increases the DNA detection rate by at least 4 times by using a semiconductor 2D material which is precipitated four times faster than conventional graphene as an additive after adsorbing single stranded DNA that is not hybridized with the dye. In addition, since the present invention is an electrochemical method using a semiconductor 2D material as an additive, a coating process in the form of a complex with a conductive material or a process using a fluorescent dye as a marker is not needed compared with a conventional MoS2-based DNA sensor, DNA can be measured economically. Further, the graphene must be surface treated to induce sedimentation at an appropriate speed (rapid precipitation occurs when the surface treatment is not performed). However, it has been difficult to add a process and ensure uniformity due to such surface treatment. However, Since the semiconductor 2D material to be used does not need such a surface treatment process, measurement reproducibility and reliability can be improved as compared with the method using graphene.