5- 5- Method for manufacturing methyl 5-bromolevulinate and manufacturing method 5-aminolevulinic acid heyl ester hydrochloride using the same

摘要

The present invention relates to a process for the production of methyl 5-bromolefuranate which is stable and can increase the yield of the final product, and a process for producing 5-aminolevulinic acid hexyl ester hydrochloride using the same. To this end, the present invention relates to a method for preparing a reaction product, comprising: a first reaction step of mixing and reacting levulinic acid, methanol and bromine in a vessel; A second reaction step of mixing and reacting the first product of the first reaction step, the first reaction product not reacted in the first reaction step, the ultra pure water and the chloroform solution, and reacting; An extraction step of extracting a chloroform solution layer from the first mixture formed after the second reaction step; A third reaction step of mixing and stirring the chloroform solution layer extracted in the extraction step, ethyl ether and sodium bicarbonate saturated solution (sodium bicarbonate); A purification step of separating the aqueous solution layer from the second mixture formed after the third reaction step; A fourth reaction step in which the remaining mixture after the aqueous solution layer is separated from the second mixture and the N-hexane are mixed and reacted; Precipitating a solid mixture of methyl 5-bromolefulinate from the third mixture while quenching the third mixture produced after the fourth reaction step; And a filtration step of filtering the solid state methyl 5-bromolephenate from a fourth mixture formed after the precipitation step using a filtration apparatus, and a process for producing methyl 5-bromolefuranate by using 5 - aminolevulinic acid hexyl ester hydrochloride.