2-2/ RECOMBINANT ANTIBODY STRUCTURES BINDING TO AND BLOCKING THE ACTIVITY OF VASCULAR ENDOTHELIAL GROWTH FACTOR 2VEGFR-2/KDR

摘要

Phage displayed recombinant antibody libraries have been developed and screened for VEGFR-2. After screening and ELISA experiments, two recombinant antibodies were obtained that showed binding properties with VEGFR-2. The differences between these two recombinant antibodies for already developed recombinant antibodies were demonstrated by DNA sequence analysis. The inhibitory effect of these two recombinant antibodies on endothelial cell proliferation has been demonstrated in cell assays. Thus, these recombinant antibodies could be used as VEGF related angiogenesis inhibitors.