- DEIMMUNIZED SERUM-BINDING DOMAINS AND THEIR USE FOR EXTENDING SERUM HALF-LIFE

摘要

The present invention relates to a polypeptide (eg antigen-binding molecule) comprising a polypeptide portion of a de-immunized serum-binding protein capable of binding a serum protein. The presence of the serum-binding protein extends the serum half-life of the polypeptide relative to the serum half-life of the polypeptide without the polypeptide portion of the de-immunized serum-binding protein. The present invention also relates to methods and uses of such molecules.