CAP1 Polypeptides that were derived from adenylyl cyclase-associated protein 1CAP1 and pharmaceutical composition comprising the same

摘要

The present invention relates to a polypeptide derived from CAP1 and a pharmaceutical composition comprising the same as an active ingredient, and more particularly, comprising an amino acid sequence of SEQ ID NO: 1, wherein 0 to 20 any amino acid at the N terminus of the sequence. , A peptide consisting of 0 to 75 additional amino acid sequences of any amino acid at the terminal C and an inflammatory disease prevention and improvement comprising the peptide as an active ingredient, anticancer and cancer metastasis prevention, diabetes prevention and improvement, It relates to a pharmaceutical composition for preventing and improving atherosclerosis or cardiovascular disease, preventing and improving heart failure. The method of the present invention has the effect of inhibiting the binding of resistin and CAP1. Since it has an effect of inhibiting NF-kB activity, it can be usefully used to treat inflammatory diseases, cancer, diabetes, arteriosclerosis, cardiovascular disease, heart failure, etc. due to activation of resistin and NF-kB activation.