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u0445u0438u043du043eu043bu0438u043du0430 derivatives for the treatment of inflammatory diseases

机译:u0445 u0438 u043d u043e u043b u0438 u043d u0430用于治疗炎症性疾病的衍生物

摘要

The present invention relates to a compound of formula (I) wherein: means an aromatic ring wherein V is C or N and when V is N; Q is N or O, provided that R" does not exist when Q is O; R' independently represent a hydrogen atom or a group chosen among a (C 1 -C 3 )alkyl group, a halogen atom, a hydroxyl group, a-COOR 1 group, a -NO 2 group, a -NR 1 R 2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C 1 -C 3 )fluoroalkyl group, a (C 1 -C 4 )alkoxy group and a -CN group, and can further be a group chosen among: or anyone of its pharmaceutically acceptable salt, for use in the treatment and/or prevention of an inflammatory disease. The invention further relates to some new compounds and to the pharmaceutical composition containing them. It further relates to screening methods.
机译:本发明涉及式(I)的化合物其中:表示芳环,其中V为C或N,且当V为N时; Q为N或O,条件是当Q为O时R“不存在; R'独立地表示氢原子或选自(C 1 -C 3)烷基,卤素原子,羟基, -COOR 1基,-NO 2基,-NR 1 R 2基,吗啉基或吗啉基,N-甲基哌嗪基,(C 1 -C 3)氟烷基,(C 1 -C 4 )烷氧基和-CN基团,并且还可以是选自以下的基团:或其任何药学上可接受的盐,用于治疗和/或预防炎症性疾病。本发明进一步涉及一些新化合物和包含它们的药物组合物。它还涉及筛选方法。

著录项

  • 公开/公告号RU2017101407A3

    专利类型

  • 公开/公告日2019-01-17

    原文格式PDF

  • 申请/专利权人

    申请/专利号RU20170101407

  • 发明设计人

    申请日0000-00-00

  • 分类号A61K31/47;

  • 国家 RU

  • 入库时间 2022-08-21 11:47:11

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