methods of treatment of patients with u0433u0435u0442u0435u0440u043eu0437u0438u0433u043eu0442u043du043eu0439 family u0433u0438u043fu0435u0440u0445u043eu043bu0435u0441u0442u0435u0440u0438u043du0435u043cu0438u0435u0439 (HEFH)

摘要

The present invention provides methods for treating hypercholesterolemia. The methods of the present invention comprise administering to patients with heterozygous familial hypercholesterolemia a pharmaceutical composition comprising a PCSK9 inhibitor. In certain embodiments, the PCSK9 inhibitor is an anti-PCSK9 antibody such as the exemplary antibody referred to herein as mAb316P. The methods of the present invention are useful for treating patients with heterozygous familial hypercholesterolemia who are not adequately controlled by maximum tolerated dose statin therapy with or without other lipid lowering therapy.