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COMPOSITIONS CONTAINING COMPLEXES OF METALS OF SERIES OF LANTHANIDES
COMPOSITIONS CONTAINING COMPLEXES OF METALS OF SERIES OF LANTHANIDES
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机译:包含镧系金属的络合物的成分
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摘要
The present invention relates to a method of removal of metal ion impurities, such as calcium, from lanthanide metal complexes of macrocyclic chelators. The method uses a scavenger resin to remove metal ions, displaced from chelator, by an excess of lanthanide ions. Also provided is a method of preparation of MRI contrast agents, from the purified lanthanide metal complex, by the addition of a defined excess chelator.
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