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NOT AN APPROPRIATE ANIMAL, FOR WHICH ARE DECREASING THE FUNCTION OF UPPER AND LOWER MOTOR NEURONS AND SENSITIVE PERCEPTION
NOT AN APPROPRIATE ANIMAL, FOR WHICH ARE DECREASING THE FUNCTION OF UPPER AND LOWER MOTOR NEURONS AND SENSITIVE PERCEPTION
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机译:不是适当的动物,因为它们会降低上,下运动神经元的功能和敏感的知觉
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摘要
An animal model for motor neuron dysfunction in disease, e.g., amyotrophic lateral sclerosis (ALS), comprising a genetically modified non-human animal that comprises a genetically modified DR6 allele and exhibits normal phenotypes at birth and for a few weeks or months after birth. However, as the non-human animal ages, it develops motor neuron dysfunction that presents as one or more ALS-like symptoms, which may progress rapidly after onset. Methods of identifying candidate agents that may be used to prevent, delay or treat ALS are also provided.
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