IMMUNOGENIC COMPOSITION CONTAINING SYNTHETIC PEPTIDES REPEATING SEQUENCE OF V3-LOOP OF SHELL PROTEIN GP120 HIV1

摘要

FIELD: immunology.SUBSTANCE: invention relates to immunology. Disclosed is an immunogenic composition comprising synthetic peptides repeating sequence of V3-loop of consensus sequence of group M and V3-loop of Russian isolate RUA022a2 of enveloping protein gp120 HIV1, presented by sequences SEQ ID NO 1 and SEQ ID NO 2, respectively, as well as immunoadjuvant for introduction into mammal.EFFECT: invention provides higher specificity of the immune response, enables to activate the immune system only on the V3-epitope responsible for the induction of neutralizing antibodies and CTL, increases the average antibody titre on V3-loop peptides, and also provides the immune response intensification.1 cl, 2 dwg, 3 ex, 1 tbl