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USING RADIOPHARMACEUTICAL COMPOSITION USING LABELLED AUTOLOGOUS LEUKOCYTES TO VISUALIZE LOCAL RADIATION LESIONS BY SINGLE-PHOTON EMISSION TOMOGRAPHY
USING RADIOPHARMACEUTICAL COMPOSITION USING LABELLED AUTOLOGOUS LEUKOCYTES TO VISUALIZE LOCAL RADIATION LESIONS BY SINGLE-PHOTON EMISSION TOMOGRAPHY
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机译:使用带标签的自动徽标白细胞的放射性药物组合物通过单光子断层显像来可视化局部辐射病变
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摘要
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to using a radiopharmaceutical composition using labelled autologous leukocytes to visualize local radiation lesions by single-photon emission tomography. For this purpose, leukocyte labelling is performed by a radiopharmaceutical composition based onIn, characterized by the following composition: indium - 11135–40 MBq, 8 - hydroxyquinoline 0.05 mg, sodium hydrocarbonate 6.72 mg, dextran with molecular weight from 30,000 to 50,000 - 30.0 mg, mannitol 15.0 mg, sodium chloride 2.7 mg, hydrochloric acid 0.05 M to 1 ml.EFFECT: invention provides high efficiency of labelling autologous leukocytes with a radiopharmaceutical composition containing as active ingredientIn, with visualization up to two days in the local radiation injury centre, which enables to perform single-photon emission computed tomography (SPECT) procedures for several days without additional administration of the radiopharmaceutical.1 cl, 1 dwg, 1 tbl, 4 ex
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机译:技术领域本发明涉及医学,即使用放射性药物组合物,该放射性药物组合物使用标记的自体白细胞通过单光子发射断层摄影术使局部放射损伤可视化。为此,可通过基于In的放射性药物组合物进行白细胞标记,其特征在于以下组成:铟-11135-40 MBq,8-羟基喹啉0.05 mg,碳酸钠6.72 mg,分子量从30,000至50,000-30.0 mg的右旋糖酐,甘露醇15.0毫克,氯化钠2.7毫克,盐酸0.05 M至1毫升。效果:本发明提供了一种以放射性药物成分为活性成分标记自体白细胞的高效方法,在局部放射损伤中心最多可观察两天,它可以执行几天的单光子发射计算机断层扫描(SPECT)程序,而无需额外施用放射性药物。1cl,1 dwg,1 tbl,4 ex
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