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IMMUNOASSAY METHOD WITH INTERFERENCE SUPPRESSION FOR DETERMINATION OF ANTIBODIES FOR DRUGS IN SERUM SAMPLES
IMMUNOASSAY METHOD WITH INTERFERENCE SUPPRESSION FOR DETERMINATION OF ANTIBODIES FOR DRUGS IN SERUM SAMPLES
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机译:干扰抑制的免疫测定法测定血清样品中的药物抗体
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摘要
FIELD: medicine.;SUBSTANCE: invention relates to medicine and relates to an enzyme immunoassay method with interference suppression for the determination of anti-drug antibodies to a therapeutically active antibody for the treatment of arthritis. Method includes: (a) incubating a sample taken from a patient with arthritis treated with the said therapeutically active antibody with a mixture containing the conjugate of the said therapeutically active antibody and the first component of the binding pair as an exciting therapeutically active antibody and a conjugate of said therapeutically active antibody and a detectable label as a detector therapeutically active antibody, to form a complex; (b) immobilization of the complex formed on stage (a) on the solid phase; (c) incubating the immobilized complex with an antibody to a detectable label of a detector therapeutically active antibody conjugated to a second detectable label, and (d) the determination of anti-drug antibodies.;EFFECT: invention provides a reduction in the number of false-positive results of the analysis of anti-drug antibodies to a therapeutically active antibody for the treatment of arthritis.;7 cl, 7 ex, 8 dwg, 9 tbl
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