METHOD FOR PREDICTING OUTCOME OF INFECTIOUS ENDOCARDITIS

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to therapy, cardiology and surgery. Method for predicting the outcome of infective endocarditis includes sampling of venous blood, isolation of genomic DNA, allele-specific polymerase chain reaction for the purpose of genotyping at the MTHFR ^{Ala222Val(C677T)} polymorphic locus of the methylenetetrahydrofolate reductase gene of persons at risk and in carriers of the genotype MTHFR ^Ala222A1a(^C677C) a favorable outcome of the disease is predicted, and in carriers of genotypes MTHFR ^{Ala222Val(C677T)}/MTHFR ^{Val222Val(T677T)} risk of death multiple of 12.33 is predicted.;EFFECT: invention can be used to predict the outcome of infective endocarditis.;1 cl, 3 ex, 3 tbl