N-PYRROLIDINYL-UREA, N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

摘要

FIELD: medicine.;SUBSTANCE: invention relates to compounds of formula I, or its stereomers, tautomers or pharmaceutically acceptable salts, where ring B and the NH-C(=X)-NH fragment are in trans configuration, and R¹, R², R^a, R^b, R^c, R^d, X, Ring B and Ring C are defined in the claims.; I.;EFFECT: compounds of formula I are inhibitors of TrkA kinase and are used to treat conditions such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.;19 cl, 2 tbl, 31 ex