COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL DISEASES

摘要

FIELD: medicine.;SUBSTANCE: group of inventions relates to medicine, specifically to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure, in particular congestive heart failure, chronic kidney disease, advanced stage kidney disease, liver disease, and fluid retention caused by a peroxisome proliferator-activated gamma receptor agonist (PPAR). Invention also relates to compounds and methods for the treatment of hypertension, for the treatment of diseases of the gastrointestinal tract, including the treatment or reduction of pain associated with gastrointestinal diseases.;EFFECT: compounds are not absorbed and are not systemically bioavailable.;11 cl, 9 tbl, 79 ex