METHOD FOR DETERMINING MANAGEMENT OF PATIENTS WITH MODERATE DYSPLASTIC CHANGES IN CERVIX UTERI

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to gynecology, and represents a method for determining the approach of patients with moderate dysplastic changes of the uterine cervix, consisting in the fact that performing a targeted point biopsy of the cervix uteri, immunohistochemical examination is carried out to determine expression of Ki-67 and CK7 markers, then the formula is used to calculate whether the patient belongs to the lower or upper subgroup of CIN 2:; ;group, where ƒ₁(a_i) = 0.266⋅X₁+0.067⋅X₂-12.519; ƒ₂(a_i) = 0.134⋅X₁+0.019⋅X₂-3.472; X₁ is Ki-67 value; X₂ is CK7 value; "0" is upper subgroup CIN 2; "1" is lower subgroup CIN 2; patients of upper CIN 2 group are predicted a progression of changes to the more severe degree CIN 3 and CIS and the cervix is excised, patients of lower CIN 2 group are predicted to regress the changes to a mild degree of CIN 1 and recommend observing for 18 months with subsequent decision on the feasibility of cervical excision.;EFFECT: method enables predicting the course of CIN 2 and determining a management approach to patients with moderate dysplastic changes in the cervix.;1 cl, 1 tbl, 2 ex;если - if;то - then