METHOD FOR PREDICTING PROGRESSIVE LIVER FIBROSIS AND SELECTING A COMBINATION OF PREPARATIONS FOR ANTIRETROVIRAL THERAPY IN CO-INFECTION OF HIV/HCV

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine and aims at selecting antiretroviral therapy for co-infection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) taking into account the threat of progressing hepatic fibrosis. Using a set of risk factors of progressive liver fibrosis in patients with HIV/HCV co-infection, liver elastometry parameters and immunological data, the high risk index of a progressive liver fibrosis is calculated by the equation: HRI=4.070+0.099*kPa+0.476*CD4-0.518*IRI, where kPa is the initial elastometry index, CD4 is the CD3+CD4+absolute number of blood cells/ml, the IRI is the immunoregulatory index. At values of HRI≤180 conclude that patient belongs to the risk group of progressive liver fibrosis.;EFFECT: method enables timely selection of therapy.;1 cl, 3 dwg, 3 tbl, 3 ex